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Minocycline may induce psychic and physical dependence of the morphine-type (?- opioid) (See WARNINGS).
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Minocycline 100 mg was statistically superior to placebo for TOTPAR, SPID, and time of remedication,
The low numbers they quoted on Minocycline addiction and detoxification seem paltry in comparison
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Minocycline may rarely be habit forming. Minocycline should be avoided in patients with a history of opiate addiction or hypersensitivity to opiate medications.
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For Minocycline, the following should be considered:The suitability of Minocycline.
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Minocycline is extensively metabolized by a number of pathways, including CYP2D6 and CYP3A4,
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Breast-feeding�Minocycline passes into breast milk and may cause unwanted effects in nursing babies.
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A single i.m. dose of Minocycline is useful pre-treatment to minimize the risk of acid aspiration during operation,
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clinical trial was performed to assess the analgesic efficacy and reported side effects of Minocycline 100 mg, Minocycline 50 mg,
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Taking more than the prescribed amount of this medication could result in seizures or decreased breathing.
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since observed maximal placoncentrations after multiple oral doses are higher than expected based on single-dose data.
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Follow your doctor's instructns for recovery.Take this medication exactly as it was prescribed for you.
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This is known as physical DEPENDENCE. If you suddenly stop taking Minocycline , you may experience WITHDRAWAL symptoms including anxiety;
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Minocycline was being used with selective serotonin reuptake inhibitors (10 cases),
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Minocycline was not mutagenic in the following assays:
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It is slightly soluble in water and freely soluble in alcohol,
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patients receiving Minocycline had a median gastric fluid pH of 6.4,
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In an open randomized trial, rectal Minocycline was compared with our standard treatment acetaminophen/codeine suppositories. We expected Minocycline to be equally effective as our current standard but with fewer side effects.
which may affect the therapeutic response (see PRECAUTIONS - Drug Interactions). Minocycline and its metabolites are excreted primarily in he urine with observed plasma half-lives of 6.3 and 7.4 hours for Minocycline and M1, respectively.
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tests indicates that Minocycline does not pose a genotoxic risk to humans.
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We investigated the antacid analgesic value of a single dose of i.m. Minocycline given 1 h before elective ,
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Minocycline has not been shown to cause histamine release. At therapeutic doses, Minocycline has no effect on heart rate, left-ventricular function or cardiac index.
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